Neuroendocrine Testicular Tumors: A Systematic Review and Meta-Analysis
Identifieur interne : 000390 ( Main/Exploration ); précédent : 000389; suivant : 000391Neuroendocrine Testicular Tumors: A Systematic Review and Meta-Analysis
Auteurs : Mseddi M. Amine [Tunisie] ; Bouzguenda Mohamed [Tunisie] ; Hadjslimane Mourad [Tunisie] ; Hamza Majed [Tunisie] ; Charfi Slim [Tunisie] ; Bouassida Mehdi [Tunisie] ; Mnif Hela [Tunisie] ; Rebai Nouri [Tunisie] ; Kallel Rim [Tunisie] ; Boudaouara Tahya [Tunisie] ; Mhiri M. Nabil [Tunisie]Source :
- Current Urology [ 1661-7649 ] ; 2017.
Abstract
The purpose of this study is to study the main epidemiological, clinical, para clinical, pathological, therapeutic, and evolutionary features of patients with testicular neuroendocrine tumors (TNET).
Nine case series and sixteen case reports were identified by searching PubMed database and qualified for inclusion in this study. We added the data of one case treated in the department of urology in Habib Bourguiba Hospital in Sfax, to the published cases.
A total of 132 cases were collected. Median age at diagnosis was 39 years old (range 10- 83 years). The most common presenting symptom was either a testicular mass or a swelling in 38.46% of cases. Carcinoid syndrome was documented in 10.60% of patients. The clinical examination revealed a palpable mass in 44.70% of patients. This mass was painless and firm in most cases. Serum tumor markers (β-gonadotrophine chorionique humaine, α-feto protein, and lactate dehydrogenase) were within normal limits in all patients except in one case. Most testicular neuroendocrine tumors (76.52%) were primary and pure. The tumors were positive for chromogranin (100%), synaptophysin (100%) and cytokeratin (93.10%). Metastases were detected at time of diagnosis in eight cases (6.06%). The main treatment was radical orchiectomy performed in 127 patients (96.21%). The 5-year overall survival rate was 78.70% and the 5-year specific survival rate was 84.30%.
The diagnosis of testicular carcinoids is based on the immunohistochemistry study. The treatment of choice for these tumors is radical orchiectomy. Somatostatin analogues were reported to be effective in patients with carcinoid syndrome.
Url:
DOI: 10.1159/000447146
PubMed: 28559773
PubMed Central: 5436018
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000291
- to stream Pmc, to step Curation: 000290
- to stream Pmc, to step Checkpoint: 000191
- to stream PubMed, to step Corpus: 000425
- to stream PubMed, to step Curation: 000424
- to stream PubMed, to step Checkpoint: 000418
- to stream Main, to step Merge: 000390
- to stream Main, to step Curation: 000390
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neuroendocrine Testicular Tumors: A Systematic Review and Meta-Analysis</title>
<author><name sortKey="Amine, Mseddi M" sort="Amine, Mseddi M" uniqKey="Amine M" first="Mseddi M." last="Amine">Mseddi M. Amine</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Department of Urology, Habib Bourguiba Hospital, Sfax</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mohamed, Bouzguenda" sort="Mohamed, Bouzguenda" uniqKey="Mohamed B" first="Bouzguenda" last="Mohamed">Bouzguenda Mohamed</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">Faculty of Medicine, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Faculty of Medicine, Habib Bourguiba Hospital, Sfax</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mourad, Hadjslimane" sort="Mourad, Hadjslimane" uniqKey="Mourad H" first="Hadjslimane" last="Mourad">Hadjslimane Mourad</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Department of Urology, Habib Bourguiba Hospital, Sfax</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Majed, Hamza" sort="Majed, Hamza" uniqKey="Majed H" first="Hamza" last="Majed">Hamza Majed</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Department of Urology, Habib Bourguiba Hospital, Sfax</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Slim, Charfi" sort="Slim, Charfi" uniqKey="Slim C" first="Charfi" last="Slim">Charfi Slim</name>
<affiliation wicri:level="1"><nlm:aff id="aff3">Department of anatomic pathology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Department of anatomic pathology, Habib Bourguiba Hospital, Sfax</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mehdi, Bouassida" sort="Mehdi, Bouassida" uniqKey="Mehdi B" first="Bouassida" last="Mehdi">Bouassida Mehdi</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Department of Urology, Habib Bourguiba Hospital, Sfax</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hela, Mnif" sort="Hela, Mnif" uniqKey="Hela M" first="Mnif" last="Hela">Mnif Hela</name>
<affiliation wicri:level="1"><nlm:aff id="aff3">Department of anatomic pathology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Department of anatomic pathology, Habib Bourguiba Hospital, Sfax</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nouri, Rebai" sort="Nouri, Rebai" uniqKey="Nouri R" first="Rebai" last="Nouri">Rebai Nouri</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Department of Urology, Habib Bourguiba Hospital, Sfax</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rim, Kallel" sort="Rim, Kallel" uniqKey="Rim K" first="Kallel" last="Rim">Kallel Rim</name>
<affiliation wicri:level="1"><nlm:aff id="aff3">Department of anatomic pathology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Department of anatomic pathology, Habib Bourguiba Hospital, Sfax</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tahya, Boudaouara" sort="Tahya, Boudaouara" uniqKey="Tahya B" first="Boudaouara" last="Tahya">Boudaouara Tahya</name>
<affiliation wicri:level="1"><nlm:aff id="aff3">Department of anatomic pathology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Department of anatomic pathology, Habib Bourguiba Hospital, Sfax</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nabil, Mhiri M" sort="Nabil, Mhiri M" uniqKey="Nabil M" first="Mhiri M." last="Nabil">Mhiri M. Nabil</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Department of Urology, Habib Bourguiba Hospital, Sfax</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">28559773</idno>
<idno type="pmc">5436018</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436018</idno>
<idno type="RBID">PMC:5436018</idno>
<idno type="doi">10.1159/000447146</idno>
<date when="2017">2017</date>
<idno type="wicri:Area/Pmc/Corpus">000291</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000291</idno>
<idno type="wicri:Area/Pmc/Curation">000290</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000290</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000191</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000191</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:28559773</idno>
<idno type="wicri:Area/PubMed/Corpus">000425</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000425</idno>
<idno type="wicri:Area/PubMed/Curation">000424</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000424</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000418</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000418</idno>
<idno type="wicri:Area/Main/Merge">000390</idno>
<idno type="wicri:Area/Main/Curation">000390</idno>
<idno type="wicri:Area/Main/Exploration">000390</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Neuroendocrine Testicular Tumors: A Systematic Review and Meta-Analysis</title>
<author><name sortKey="Amine, Mseddi M" sort="Amine, Mseddi M" uniqKey="Amine M" first="Mseddi M." last="Amine">Mseddi M. Amine</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Department of Urology, Habib Bourguiba Hospital, Sfax</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mohamed, Bouzguenda" sort="Mohamed, Bouzguenda" uniqKey="Mohamed B" first="Bouzguenda" last="Mohamed">Bouzguenda Mohamed</name>
<affiliation wicri:level="1"><nlm:aff id="aff2">Faculty of Medicine, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Faculty of Medicine, Habib Bourguiba Hospital, Sfax</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mourad, Hadjslimane" sort="Mourad, Hadjslimane" uniqKey="Mourad H" first="Hadjslimane" last="Mourad">Hadjslimane Mourad</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Department of Urology, Habib Bourguiba Hospital, Sfax</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Majed, Hamza" sort="Majed, Hamza" uniqKey="Majed H" first="Hamza" last="Majed">Hamza Majed</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Department of Urology, Habib Bourguiba Hospital, Sfax</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Slim, Charfi" sort="Slim, Charfi" uniqKey="Slim C" first="Charfi" last="Slim">Charfi Slim</name>
<affiliation wicri:level="1"><nlm:aff id="aff3">Department of anatomic pathology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Department of anatomic pathology, Habib Bourguiba Hospital, Sfax</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mehdi, Bouassida" sort="Mehdi, Bouassida" uniqKey="Mehdi B" first="Bouassida" last="Mehdi">Bouassida Mehdi</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Department of Urology, Habib Bourguiba Hospital, Sfax</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hela, Mnif" sort="Hela, Mnif" uniqKey="Hela M" first="Mnif" last="Hela">Mnif Hela</name>
<affiliation wicri:level="1"><nlm:aff id="aff3">Department of anatomic pathology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Department of anatomic pathology, Habib Bourguiba Hospital, Sfax</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nouri, Rebai" sort="Nouri, Rebai" uniqKey="Nouri R" first="Rebai" last="Nouri">Rebai Nouri</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Department of Urology, Habib Bourguiba Hospital, Sfax</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rim, Kallel" sort="Rim, Kallel" uniqKey="Rim K" first="Kallel" last="Rim">Kallel Rim</name>
<affiliation wicri:level="1"><nlm:aff id="aff3">Department of anatomic pathology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Department of anatomic pathology, Habib Bourguiba Hospital, Sfax</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tahya, Boudaouara" sort="Tahya, Boudaouara" uniqKey="Tahya B" first="Boudaouara" last="Tahya">Boudaouara Tahya</name>
<affiliation wicri:level="1"><nlm:aff id="aff3">Department of anatomic pathology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Department of anatomic pathology, Habib Bourguiba Hospital, Sfax</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nabil, Mhiri M" sort="Nabil, Mhiri M" uniqKey="Nabil M" first="Mhiri M." last="Nabil">Mhiri M. Nabil</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Urology, Habib Bourguiba Hospital, Sfax, Tunisia</nlm:aff>
<country xml:lang="fr">Tunisie</country>
<wicri:regionArea>Department of Urology, Habib Bourguiba Hospital, Sfax</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Current Urology</title>
<idno type="ISSN">1661-7649</idno>
<idno type="eISSN">1661-7657</idno>
<imprint><date when="2017">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Purpose</title>
<p>The purpose of this study is to study the main epidemiological, clinical, para clinical, pathological, therapeutic, and evolutionary features of patients with testicular neuroendocrine tumors (TNET).</p>
</sec>
<sec><title>Materials and Methods</title>
<p>Nine case series and sixteen case reports were identified by searching PubMed database and qualified for inclusion in this study. We added the data of one case treated in the department of urology in Habib Bourguiba Hospital in Sfax, to the published cases.</p>
</sec>
<sec><title>Results</title>
<p>A total of 132 cases were collected. Median age at diagnosis was 39 years old (range 10- 83 years). The most common presenting symptom was either a testicular mass or a swelling in 38.46% of cases. Carcinoid syndrome was documented in 10.60% of patients. The clinical examination revealed a palpable mass in 44.70% of patients. This mass was painless and firm in most cases. Serum tumor markers (β-gonadotrophine chorionique humaine, α-feto protein, and lactate dehydrogenase) were within normal limits in all patients except in one case. Most testicular neuroendocrine tumors (76.52%) were primary and pure. The tumors were positive for chromogranin (100%), synaptophysin (100%) and cytokeratin (93.10%). Metastases were detected at time of diagnosis in eight cases (6.06%). The main treatment was radical orchiectomy performed in 127 patients (96.21%). The 5-year overall survival rate was 78.70% and the 5-year specific survival rate was 84.30%.</p>
</sec>
<sec><title>Conclusion</title>
<p>The diagnosis of testicular carcinoids is based on the immunohistochemistry study. The treatment of choice for these tumors is radical orchiectomy. Somatostatin analogues were reported to be effective in patients with carcinoid syndrome.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>Tunisie</li>
</country>
</list>
<tree><country name="Tunisie"><noRegion><name sortKey="Amine, Mseddi M" sort="Amine, Mseddi M" uniqKey="Amine M" first="Mseddi M." last="Amine">Mseddi M. Amine</name>
</noRegion>
<name sortKey="Hela, Mnif" sort="Hela, Mnif" uniqKey="Hela M" first="Mnif" last="Hela">Mnif Hela</name>
<name sortKey="Majed, Hamza" sort="Majed, Hamza" uniqKey="Majed H" first="Hamza" last="Majed">Hamza Majed</name>
<name sortKey="Mehdi, Bouassida" sort="Mehdi, Bouassida" uniqKey="Mehdi B" first="Bouassida" last="Mehdi">Bouassida Mehdi</name>
<name sortKey="Mohamed, Bouzguenda" sort="Mohamed, Bouzguenda" uniqKey="Mohamed B" first="Bouzguenda" last="Mohamed">Bouzguenda Mohamed</name>
<name sortKey="Mourad, Hadjslimane" sort="Mourad, Hadjslimane" uniqKey="Mourad H" first="Hadjslimane" last="Mourad">Hadjslimane Mourad</name>
<name sortKey="Nabil, Mhiri M" sort="Nabil, Mhiri M" uniqKey="Nabil M" first="Mhiri M." last="Nabil">Mhiri M. Nabil</name>
<name sortKey="Nouri, Rebai" sort="Nouri, Rebai" uniqKey="Nouri R" first="Rebai" last="Nouri">Rebai Nouri</name>
<name sortKey="Rim, Kallel" sort="Rim, Kallel" uniqKey="Rim K" first="Kallel" last="Rim">Kallel Rim</name>
<name sortKey="Slim, Charfi" sort="Slim, Charfi" uniqKey="Slim C" first="Charfi" last="Slim">Charfi Slim</name>
<name sortKey="Tahya, Boudaouara" sort="Tahya, Boudaouara" uniqKey="Tahya B" first="Boudaouara" last="Tahya">Boudaouara Tahya</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/MaghrebDataLibMedV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000390 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000390 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= MaghrebDataLibMedV2 |flux= Main |étape= Exploration |type= RBID |clé= PMC:5436018 |texte= Neuroendocrine Testicular Tumors: A Systematic Review and Meta-Analysis }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28559773" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a MaghrebDataLibMedV2
This area was generated with Dilib version V0.6.38. |